Prostate cancer is the second most frequently diagnosed cancer in men

Prostate cancer is the second most frequently diagnosed cancer among men with 1 in 8 men likely to be diagnosed with prostate cancer in his lifetime. There are an estimated three million men living with prostate cancer in the U.S.

Prostate Cancer Stages

Stages
1 and 2

In early stages of the disease, prostate cancer is limited to the prostate glands.

Approximately one third of patients with early stage prostate cancer will experience rising levels of prostate specific antigen, an indication that the disease is progressing.
Stage 3

In Stage 3, the prostate cancer has spread to nearby tissues and organs.

If the cancer spreads despite treatment to reduce male hormone levels, the disease is referred to as castration-resistant prostate cancer (CRPC). Approximately 80% of men with CRPC develop metastatic CRPC, a form of Stage 4 prostate cancer.
Stage 4

Stage 4 prostate cancer is the most advanced form of the disease.

The cancer has spread beyond the prostate to nearby organs and distant organs, such as lymph nodes or bone.

ESSA's Novel Approach to Prostate Cancer

The standard prostate cancer treatment often includes the administration of both androgen deprivation therapy (ADT) and antiandrogen therapy. While initially effective, these treatments often become ineffective due to resistance mechanisms that occur in patients involving the ligand-binding domain of the androgen receptor.

ESSA is developing an investigational treatment for prostate cancer, EPI-7386, which blocks the N-terminal domain of the androgen receptor, located on the opposite end of the receptor from the ligand-binding domain. EPI-7386 inhibits androgen receptor-driven biology, which may provide a benefit to prostate cancer patients at various stages of the disease.

Learn More

Resources

For more information on prostate cancer, additional resources and ways to connect with the community, visit the links below.

Prostate Cancer

Prevalence

Prostate Cancer Stages

Stages
1 and 2

Stage 3

Stage 4

ESSA's Novel Approach to Prostate Cancer

Resources

Canada

United States

United States

Stages 1 and 2

Stage 3

Stage 4

Stages
1 and 2